A randomised controlled trial to investigate the use of high-frequency airway oscillations as training to improve dyspnoea in COPD

This paper describes the design of a randomized, double-blind, sham-controlled trial that will examine the use of a high-frequency airway oscillating device for improving dyspnea and sputum retention in patients with COPD. The primary outcome measure is the change in CRQ-SR dyspnea domain; secondary endpoints are lung function, exercise capacity, physical activity, and health-related QoL. Lung function at the start of the study and at follow-up will be assessed using the Vitalograph Alpha spirometer.