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Cough Studies
Exceptional expertise in cough studies and cough monitoring.
What Vitalograph Offer
A cough study’s success depends on swift, accurate, high-quality data. The VitaloJAK® Cough Monitor provides the only fully validated system for objective measurement of cough with median sensitivity >99% and excellent integrity.
Our compact, mobile monitoring system allows home-based ambulatory recording over 24 hours, allowing subjects to continue their normal daily activity while participating in your trial. Cough recordings undergo centralised, semi-automated analysis to provide quantified data. The VitaloJAK algorithm removes non-cough data from cough recordings, reducing the file size to allow efficient analysis by trained cough analysts.
VitaloJAK is a validated, 510k cleared and CE marked medical device system.
Our experienced teams include cough, project and data management experts. They coordinate and manage all the project essentials for the Vitalograph aspect of the study including project planning, risk assessment, budget control, tracking information, creating customisable reports, reviewing data, status updates and change control. Their aim is to ensure that your trial runs smoothly, on time, to scope and on budget.
We offer:
Clinical trial devices and software.
An expert cough analysis service.
Professional and dedicated study services. 
Enabling the objective study of cough.
Our Experience
Highly experienced cough experts, innovative devices, our unrivalled experience is at your disposal.
The VitaloJAK® Cough Monitor has proven suitable for quantifying 24 hour cough sessions in large Phase 2 and 3 studies where other methods of cough data collection and analysis are too costly, time consuming or inconsistent. 
The system has been used for research since 2005 and in phase 2 and 3 studies globally since 2014. It has been fully validated by the specialist cough research unit at the Manchester University NHS Foundation Trust UK, through multiple phase 1 and academic research studies.
Number of studies: 54
Number of molecules assessed: 20
Total coughs counted: 17,485,000 
Total number of sessions: 29,578
(November 2023)
“Measures of both intra- and inter-rater reliability for both filtered and full-length 24-hour recordings were found to be excellent, exceeding a reliability of 0.99” 
Mines et al. Assessment of Inter- and Intra- Rater Reliability of Objective Cough Frequency in patients with Chronic Cough. European Respiratory Journal 2019; 54: Suppl. 63, PA4342
Measurement Objectives & Endpoints
The objective frequency of cough is the preferred assessment of cough in clinical trials.
We offer a robust, customisable system for the measurement and analysis of cough study data in Phase I – IV trials. The study reports can be tailored to your needs so that the primary, secondary and/or exploratory endpoints can be reviewed on a regular basis, giving you live overview of your study.
Criteria | Example Endpoints |
Cough counts |
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Events |
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Case Study
Cough: Study solutions for a global trial
A customer was conducting a suite of phase II/III Clinical trials to investigate the efficacy and safety of an investigational medicinal product in patients with chronic cough. These were global studies with >300 sites, >3000 VitaloJAKs and 30,000 sensor kits and data cards.
