The chain mediating role of C-reactive protein and triglyceride-glucose index between lung function and cognitive function in a systemic low-grade inflammation state

This prospective cohort study examined whether serum CRP and the triglyceride-glucose index explained the association between lung function and subsequent cognitive function impairment in subjects with systemic low-grade inflammation; the study was conducted in 1742 middle-aged and elderly adults (age ≥50 years) in England who were enrolled in ELSA. As part of the study, lung function testing (FEV1, FVC) was undertaken using the handheld Vitalograph Escort spirometer.