Morphine for treatment of cough in idiopathic pulmonary fibrosis (PACIFY COUGH): A prospective, multicentre, randomised, double-blind, placebo-controlled, two-way crossover trial

Disease Areas:
Cough, IPF
Device Types:
VitaloJAK

This Phase 2, multicenter, randomized, double-blind, two-way crossover trial examined the anti-tussive effects of low-dose controlled-release morphine, as compared with placebo, in 44 patients with idiopathic pulmonary fibrosis. The primary endpoint was the percent change from baseline to treatment end in daytime/awake cough frequency. Cough was objectively monitored using the Vitalograph VitaloJAK cough monitor.

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