Nicotine as a factor in stress responsiveness among detoxified alcoholics

This randomized, double-blind trial examined the effect of low- or high-dose transdermal nicotine, as compared with placebo, on stress reactivity following a psychosocial stressor in 51 currently smoking, detoxified, substance-dependent individuals. As part of the study, overnight smoking abstinence was confirmed using the Vitalograph BreathCO monitor.