Oral protein energy supplements for children with cystic fibrosis: CALICO multicentre randomised controlled trial

This was a multicenter randomized controlled trial that examined whether long-term use of oral protein energy supplements improved nutritional and other clinical outcomes in 102 moderately malnourished children with cystic fibrosis. The primary endpoint was the 12-month change in BMI centile. Spirometric lung function parameters included FEV1 and FVC, and were measured using a Vitalograph portable spirometer.