Isradipine enhancement of virtual reality cue exposure for smoking cessation: Rationale and study protocol for a double-blind randomized controlled trial

This paper describes the design of a double-blind, randomized trial that will evaluate the effect of isradipine versus placebo on the extinction of self-reported craving in adult cigarette smokers; planned recruitment is 102 subjects aged 18–65 years. Abstinence status will be verified using the Vitalograph BreathCO carbon monoxide monitor.