The interaction of genes and smoking on forced expiratory volume: A classic twin study

This study examined the heritability of the ratio of measured FEV1 to expected FEV1, as well as the interaction between genetic factors and smoking on this ratio, in 475 monozygotic and 1054 dizygotic twin pairs from the TwinsUK registry. During the study, in-clinic lung function testing was undertaken using the Vitalograph wedge bellows spirometer.