Heterozygous Vangl2(Looptail) mice reveal novel roles for the planar cell polarity pathway in adult lung homeostasis and repair

This study examined the effect of single nucleotide polymorphisms in the VANGL2 gene on lung function in a population-based sample of 5139 adults aged 31 years who were enrolled in the Finnish NFBC1966 birth cohort study. Included subjects underwent lung function testing (FEV1, FVC, FEV1/FVC ratio) using a Vitalograph wedge bellows spirometer.