Upper limb evaluation in Duchenne muscular dystrophy: Fat-water quantification by MRI, muscle force and function define endpoints for clinical trials

This study explored the usefulness of upper limb MRI muscle fat as a non-invasive objective endpoint for disease progression in 15 non-ambulant male children with Duchenne muscular dystrophy and 10 age- and gender-matched healthy control subjects. Lung function and PCF were evaluated using a Vitalograph Pneumotrac spirometer