Use of sputum eosinophil counts to guide management in children with severe asthma

This randomized controlled study investigated the success of symptom-based management versus sputum eosinophil-based management in 55 children with severe asthma. Primary outcomes were the rate of major exacerbations and asthma control as assessed by symptom-free days and use of SABAs. Baseline spirometry was performed using a Vitalograph COMPACT portable spirometer.