A large-scale genome-wide association analysis of lung function in the Chinese population identifies novel loci and highlights shared genetic aetiology with obesity

This study used data from the China Kadoorie Biobank and UK Biobank to: (i) identify novel genetic risk loci for lung function traits in a Chinese population; (ii) investigate shared genetic effects between lung function and obesity traits in Chinese and European populations; and (iii) evaluate whether BMI affects lung function. Within the UK Biobank, lung function testing (FEV1, FVC) was undertaken using the Vitalograph Pneumotrac spirometer.