Targeting TRP channels for chronic cough: From bench to bedside

This review provided an overview of airway sensory nerves and the cough reflex, highlighting the role of the TRP family of ion channels as potential therapeutic targets. In-clinic measurements of cough were examined, including use of ambulatory cough monitors such as the Vitalograph VitaloJAK. The VitaloJAK was described by the authors as a "custom-made digital recording device" that comprises "a compression algorithm that removes silence and the bulk of non-cough sounds from 24-h acoustic recordings". Per published and unpublished data from patients with chronic cough, asthma, COPD, lung cancer and healthy controls, the VitaloJAK "provides a sound file an average of 85 min in length containing median 100.0 % (range 97.3–100 %) of coughs in the original 24-h recording"