Vitamin C supplementation to pregnant smokers alters asthma- and allergy-associated CpGs in child buccal DNA at 5 years of age

This study examined the association between vitamin C treatment, lung function, and buccal DNA methylation in 137 participants from a randomized, double-blind trial that evaluated airway function and wheeze in infants and children born to pregnant smokers treated with vitamin C or placebo. Lung function testing was performed when the offspring were aged 5 years using a Vitalograph Pneumotrac spirometer.